Software Engineer

Software Engineer

Position Summary:

Gritstone Oncology is a privately-held, next-generation personalized cancer immunotherapy company. Gritstone brings together distinguished scientific founders, an experienced and diverse management team, a seasoned and successful board of directors and deep financial backing to tackle fundamental challenges at the intersection of cancer genomics, immunology, and immunotherapy design. The Company’s initial goal is to identify and deploy neoantigens for novel treatments of patient with common solid cancers. In addition to neoantigen therapy development, Gritstone is leveraging its unique antigen discovery platform to define targets for shared antigen immunotherapies, which would provide an opportunity to treat even more patients.

Gritstone Oncology is headquartered in the San Francisco Bay Area with key functions located in Cambridge, MA and Pleasanton, CA. The company launched in October 2015 and has received funding from leading blue-chip biotechnology investors, including Versant Ventures, The Column Group, Clarus Funds, and Google Ventures (GV).

Gritstone Oncology is seeking a Software Engineer to build and support our software systems for analyzing cancer patient data. Our cloud-based architecture was recently featured by Amazon Web Services:

https://aws.amazon.com/partners/success/gritstone-oncology/

This is an opportunity to work for a well-funded early biotechnology company where design of personalized cancer treatments is powered by cloud technology. In this role, you will work closely with our engineering, IT and scientific teams to expand and optimize the capabilities of our system. We are looking for an independent and flexible team player who will thrive in a fast-paced, dynamic, and highly collaborative environment.

Specific Roles and Responsibilities:

  • Design and integrate improvements to Gritstone’s cloud systems used by our scientific teams for data processing and data access.
  • Work closely with IT and QA teams to integrate new production systems safely, securely and in compliance with QA requirements. Engage our external vendors for support and service requests.
  • Use modern, secure methods and tools for development, deployment, monitoring and maintenance of our systems. Leverage automation and infrastructure-as-code everywhere possible.
  • Explore and evaluate new technology and help influence our choices for future system architecture.
  • Understand our business mission and drive technical progress in support of our company goals.
  • Learn, grow and apply new skills to optimize our processes. We encourage skill development and learning through training, conferences, and workshop attendance. We also encourage participation in industry associations and we support opportunities to present/publish your work where appropriate.

Minimum Education/Experience:

  • 5+ years of experience in a software or system engineering role
  • Experience managing Linux server environments
  • Experience managing virtualized or cloud infrastructure: deployment, maintenance, monitoring and security activities
  • Fluency in one or more programming languages (Python, Ruby, Go) and development tools
  • Experience with configuration management, (Chef, Ansible, Puppet, Packer, etc), build  systems (Jenkins, CodePipeline, etc), and version control (git)
  • Bachelor’s degree in STEM discipline

Preferred Qualifications:

  • Deep expertise with AWS environments (e.g. IAM Roles and Policies, EC2, S3, RDS, CloudFormation, CloudTrail, CloudWatch). AWS Certifications are a plus.
  • Experience supporting scientific computing operations (astronomy, genomics, etc)
  • Experience in bio-pharma or regulated environments
     

Assistant Controller / Controller

Assistant Controller / Controller

Position Summary:

The primary responsibilities of the Assistant Controller / Controller will be to oversee the accounting function, including internal and external financial reporting. The Assistant Controller / Controller is a multi-faceted leadership position, managing SEC Reporting & SOX 404; Corporate Accounting; Accounting and Financial Assurance; Financial Planning and Analysis.

Specific roles and responsibilities include:

  • Responsible for all aspects of the day-to-day activities of the accounting department, including transaction processing, accounting close process, and accurate preparation of financial accounting results and management reporting.
  • Evaluation, implementation and maintenance of financial software systems.
  • Serve as a technical subject matter expert to include: developing, maintaining and enforcing accounting policies and procedures in accordance with US GAAP and other authoritative literature; leading analysis of the application of technical accounting standards to complex business issues and transactions and providing well-supported documentation of positions and conclusions; and overseeing SEC reporting guidelines.
  • Keeps informed of current developments in the field of US GAAP standards, other authoritative standards, new legislation, professional trends, and technological advances within biopharmaceutical industry.
  • Ensure the timely and accurate preparation of monthly, quarterly and annual financial statements (and related footnote disclosures) in accordance with US GAAP.
  • Oversee the timely and accurate preparation of external financial reporting, including the drafting and finalization of Forms 10-Q, 10-K and other SEC filings as required, in compliance with SEC regulations and US GAAP disclosure requirements.
  • Serve as primary contact for and manage external audit and tax service providers.
  • Design and implement strong internal controls and oversee execution and testing of controls to ensure overall compliance with SOX 404 requirements.
  • Key participant in the budgeting and forecasting process.  Perform periodic budget vs actual analyses.
  • Oversee tax planning, compliance and filings, including corporate income tax, and sales and use tax.
  • Manage, mentor and develop a high performing and collaborative finance team. 
  • Keeps informed of current developments in the field of US GAAP standards, other authoritative standards, new legislation, professional trends, and technological advances within biopharmaceutical industry.
  • Other duties and projects as assigned to make this job a career building experience.

Requirements:

Minimum Education/Experience

  • BS/BA degree in accounting, with a CPA license and extensive background working in both public accounting and industry.
  • At least 10 years of finance and accounting experience in a fast-paced, results-oriented, hands-on environment at a small to medium size publicly-traded company, preferably in the life sciences, medical technology or diagnostics industries.
  • Ability to be visionary in building an experienced and high-performing accounting team to commensurate with the growth of the Company.
  • Team-oriented with outstanding integrity, accuracy and organizational skills.
  • Ability to proactively identify and solve problems.
  • Demonstrate excellent written and oral communication skills to facilitate interaction with all levels of an organization and outside audiences as well as excellent listening skills; open and responsive to new ideas.
  • A positive, self-confident, decisive leader, with a track record in developing high performing teams, and leveraging a collaborative, coaching approach in management style.
  • Computer skills: Functional experience with an ERP; proficiency in MS Office applications such as; Excel, Word, Access, and PowerPoint.
  • Experience in system implementation.

Other Qualifications

  • Strong organizational skills and attention to detail.
  • Able to work effectively in a fast-paced, small start-up company environment.
  • Self-motivated, self-disciplined and able to function independently as well as part of a team.
  • Strong ability to prioritize, multi-task, and work in an evolving environment.
  • Excellent written/verbal communication skills.

 

Corporate Counsel

Corporate Counsel

Position Summary:

The person who fills the Corporate Counsel position will be the second in-house attorney at Gritstone, an innovative, fast-paced oncology biotech.  We are a tightly-knit, hard-working, friendly company with a noble goal—curing cancer.  As part of a small but efficient and productive legal team, the Corporate Counsel will have opportunity to explore, tackle and solve a wide variety of legal issues as they converge with scientific and business matters, and therefore, must be an agile thinker, have a keen eye for spotting issues, possess a flexible, practical and thoughtful approach to solving complex legal and business issues, and have an excellent work ethic, topped off with a friendly, professional and courteous demeanor.  The person in this role must be intellectually curious and ready to enthusiastically tackle novel legal and industry issues.

The responsibilities of the Corporate Counsel include, but are not limited to:

  • Draft, negotiate and manage agreements for all company departments, including Clinical Operations, Manufacturing, Research, Finance, Regulatory/Quality, HR, etc.
  • Assist with development, training and implementation of policy, with supervision from Associate General Counsel and with input from relevant stakeholders.
  • Research, assess, and concisely advise internal clients on wide variety of legal issues as they arise. 
  • Travel quarterly to the Cambridge, MA facility to support internal clients at that GMP manufacturing laboratory facility.
  • Regularly visit Pleasanton, CA manufacturing facility to support colleagues in person.
  • Prepare and deliver training materials to variety of internal client audiences on topics from compliance, to confidentiality, to trade secrets and beyond. 
  • Research and prepare accurate and concise memos/advice to Associate General Counsel regarding complex issues such as EU General Data Privacy Act, export/import controls, and more.
  • Administrative and paralegal functions as necessary to support the Legal Department and the company.

Minimum Education/Experience:

  • JD (Juris Doctor) degree from a top accredited law school with membership in good standing at the bar.
  • 5+ years legal practice experience with at least 2 years representing Life Sciences clients.
  • Minimum  of 2 years  experience negotiating agreements for biotech/pharmaceutical clients.     
  • Have extensive experience representing Life Sciences clients.  
  • Have at least 3 years’ experience at a top law firm. 
  • Preference for candidates who have spent at least 2 years in-house at a biotech/pharmaceutical company. 
  • Experience in general securities and corporate law with an emphasis on representing public and private companies a plus
  • Experience with IP portfolios (patent) a plus
  • Experience in healthcare compliance a plus
  • Strong communication, teamwork, interpersonal, and negotiation skills

Other Qualifications:

  • Strong organizational skills and attention to detail
  • Able to work effectively in a fast-paced, small start-up company environment
  • Self-motivated, self-disciplined and able to function independently as well as part of an executive team
  • Strategic agility, strong critical, and logical thinking with ability to analyze problems
  • Strong ability to prioritize, multi-task, and work in an evolving environment 
  • Excellent presentation and written/verbal communication skills
  • Professional and courteous demeanor

 

 

Research Associate/Senior Research Associate, Translational Immunology

Research Associate/Senior Research Associate, Translational Immunology

Position Summary

The Research Associate/Senior Research Associate, Translational Immunology will be responsible for performing and analyzing experiments in the field of immunology. RA/SRA will be involved in immune monitoring of clinical trial and in exploratory research. We are looking for an experienced, motivated, independent and flexible team player who will thrive in a high-pace dynamic environment.

Responsibilities

  • Develop, perform and analyze assays including, but not limited to, flow cytometry, ELISA, Elispot, live cell sorting, transcriptional analyses, transfection and transduction
  • Isolation of various cell types from human blood and tissues
  • Cell culture, including primary cultures, development and maintenance of cell lines 
  • Contribute to inter-disciplinary research efforts in a cross-functional setting
  • Design, perform and analyze experiments 
  • Assist in effort to establish and qualify assays for clinical trials
  • Assist in management and procurement of research samples 
  • Real-time updating of sample, reagent and data logs 
  • Maintain experimental records in electronic lab notebook format
  • Perform general laboratory duties including reagent preparation and aliquoting, lab equipment maintenance, ordering and receiving of lab supplies

Qualifications

  • B.S., B.A. or M.S. with a degree in immunology, biology or related field with 2-5+ years of laboratory experience (title will be adjusted based on level of experience)
  • Hands-on expertise in methodologies, reagents and instrumentation used for primary cell culture, flow cytometry, and transcriptional analyses
  • Highly organized with excellent record keeping skills
  • Focus on delivery of stable, reliable solutions
  • Ability to prioritize and complete tasks and advance projects
  • Ability to interact adaptably with scientists and non-scientists from various disciplines
  • Excellent written and verbal communication skills
  • A good work ethic and willingness to participate in a fast-pace work environment are essential
  • Computer fluency is essential
  • Experience in clinical trial immune monitoring and LIMS system is a plus

Education/Experience

B.S., B.A. or M.S. with a degree in immunology, biology or related field with 2-5+ years of laboratory experience.

 

 

 

Specialist/Sr.  Specialist or Manager/Sr. Manager, Quality Assurance Batch Release

Specialist/Sr. Specialist or Manager/Sr. Manager, Quality Assurance Batch Release

Position Summary:

The Specialist/Sr.  Specialist Quality Assurance Batch Release will partner with Manufacturing in the development and approval of Master Batch Records (MBR).  This position will also provide Quality reviews of and disposition of Executed Batch Records (EBR) and associated supporting documentation for the production of clinical products.  Additionally, this position will support any other GMP documentation reviews required for QA Batch Release.

The Specialist/Senior Specialist Quality Assurance Batch Release supports the drug product manufacturing process with the following responsibilities:

  • Responsible for the development/review/approval of MBRs

  • Responsible for the review and approval of EBRs

  • Work with internal manufacturing or CMOs as necessary to address any comments or corrections identified during the EBR review process

  • Confirm all deviations and investigation reports are closed prior to approval of EBRs

  • Collect and organize all required manufacturing documentation necessary for release of DS/DP

  • Maintain a batch record review schedule to ensure on-time product disposition

Additional responsibilities for the Manager/Sr. Manager Batch Release may include:

  • Manage CMO relationships with respect to Quality
  • Manage the Company Stability Program including Drug Substance, Drug Product for both internal and CMO manufacturing
  • Partner with QC on the review/approval of stability data
  • Review Stability protocols/reports as required

Minimum Education/Experience

  • Bachelor’s degree (or equivalent), preferably in scientific discipline or a health-related field and at least 2 years of experience reviewing Batch Documentation in the Pharmaceutical industry

  • Working knowledge of FDA and EMA GMP regulation and ICH guidance documents

  •  Experience in the manufacture of biopharmaceutical drug substance and drug products.

Other Qualifications

  • Strong organizational skills and attention to detail

  • Able to work effectively in a fast-paced, small start-up company environment

  • Self-motivated, self-disciplined and able to function independently as well as part of a team

  • Strategic agility, strong critical and logical thinking with ability to analyze problems

  • Strong ability to prioritize, multi-task, and work in an evolving environment

  • Excellent presentation and written/verbal communication skills

  • Excellent computer proficiency (MS Word, Excel, PowerPoint)

 

Director/Senior Director, Vaccine Technologies

Director/Senior Director, Vaccine Technologies

Position Summary:

The Director/Senior Director of Vaccine Technologies will lead a molecular biology and virology team that develops cancer vaccines consisting of personalized tumor neo-epitope expression cassettes delivered by potentially various vaccine platforms such as self replicating RNA, viruses and plasmid.

Specific Responsibilities:

  • Recruitment and line management of lab scientists and technicians. 

  • Management and hands-on responsibility for vaccine development, including design and optimization of personalized multi-epitope expression cassette delivered by various vaccine platforms with strong focus on RNA based vaccines.

Requirements and Education:

  • PhD in Molecular Biology, Virology, or related field

  • Strong academic track record with >5 years in industry, 4+ in management

  • Significant track record of accomplishment as evidenced by launched products or core contributions to publications

Skills and Qualifications:

  • Excellent experience in developing self replicating RNA vaccines with expertise in molecular biology and virology techniques. Experience with Adenovirus, Lentivirus or plasmid vaccines preferred.

  • Strong management skills with managing a diverse group of scientists focusing on the development of various vaccine platforms

  • Excellent written and verbal communication skills
  • A good work ethic and willingness to participate in a fast-pace work environment are essential

Bioinformatics Scientist

Bioinformatics Scientist

Position Summary:

Gritstone Oncology is seeking a Bioinformatics Scientist to help harness the immune system to treat cancer. The Bioinformatics Scientist will perform analyses of industry leading proprietary and public genomic and proteomic datasets to find actionable biological insights. 

 We are looking for an independent and flexible team player who will thrive in a fast-paced, dynamic, and highly collaborative environment. This is an opportunity to work for a well-funded early biotechnology company where bioinformatics analyses drive personalized cancer treatments.

 Specific responsibilities:

  • Develop and perform novel, rigorous bioinformatics analyses
  • Work closely with other computational and experimental scientists to design experiments
  • Effectively communicate findings to stakeholders

 Minimum Education/Experience:

  • PhD in Bioinformatics, Computer Science, Biostatistics, or a related field, or BA/MS plus 3+ years of comparable work experience
  • Training and experience in applying rigorous statistical methods for hypothesis testing to biological data
  • Track record of success in analyzing Mass Spectrometry or NGS data 

Desired Experience:

  • Applying in-depth knowledge of cancer biology
  • Analysis of large, publicly-available datasets (e.g. GTEx, TCGA, ExAC)
  • Coding in python including Pandas
  • Software engineering including writing production-level code
  • Analysis of single cell data
  • Working in the cloud or on a high-performance computing cluster

 

Associate Director, Cost Accounting

Associate Director, Cost Accounting

Position Summary:

The Associate Director, Cost Accounting position will play an integral role in the finance department, as well as provide cost and managerial accounting leadership to the entire Company.  The Cost Accounting function will work with, and support, both financial operations and general accounting to drive costing oversight and compliance.  The position will contribute to the development of the Manufacturing annual budget and subsequent reforecasts, cost rollups/inputs, and cost reduction plans.  In addition, the position will play an integral part in identifying areas of improvement and cost efficiency.  This position will perform special accounting projects as required.

 Key roles and responsibilities include: 

  • Lead the strategic direction of the cost accounting function, and act as a liaison between Manufacturing and the Finance Department, on all aspects of cost accounting.

  • Construct, maintain and update financial models for current and anticipated Manufacturing workflows and related costs.

  • Provide technical guidance, mentoring, and guidance, and ensure consistent application of cost accounting principles at our Manufacturing site, as well as external manufacturing vendors.

  • Act as key contributor to the Company’s annual planning and budgeting process for the Manufacturing group, including both expense and capital equipment requirements.  Provide budgeting and accounting direction to Manufacturing and related departments.

  • Develop new, robust processes to drive productivity in the cost accounting function.

  • Work with the Manufacturing operations group to identify cost saving opportunities, and continually analyze product cost inputs.

  • Ensure that proper controls and procedures are in place for the tracking and valuation of business assets and inventory. 

  • Lead monthly close process for cost accounting tasks, analyze manufacturing variances, review and approve journal entries and monthly balance sheet reconciliations.

  • Assist with the coordination and deliverables for quarterly reviews and annual audits performed by external auditors.

  • Prepare ad hoc analyses and assist team with research on cost accounting questions and assist with special projects as requested.

  • Assist in selection and implementation of ERP system.

 Minimum Education/Experience:

  • Bachelor’s degree in Business Administration with Accounting or Finance concentration; MBA preferable and/or CPA or CMA certification.

  • 7 – 10 years of direct experience in accounting, reporting and costing leadership within a medium to large operating company.

  • Cost accounting/manufacturing accounting background with in-depth knowledge of GAAP and financial reporting for a manufacturing organization.

Other Qualifications:

  •  Excellent judgement and creative problem-solving skills.

  • Strong knowledge of cost accounting principles including capitalization of variances and experience with rolling standard costs.

  • Ability to influence and engage business partners, peers, direct/indirect reports, and effectively interface with senior management.

  • Strong organizational and team building skills and proven ability to work with a diverse group of people.

  • Able to work effectively in a fast-paced, small start-up company environment, and adapt quickly to changing priorities.

  • Self-motivated, self-disciplined and able to function independently as well as part of a cohesive team.

  • Strong ability to prioritize, multi-task, and work in an evolving environment.

  • Excellent written and verbal communication skills.

  • Experience in using an ERP system.

  • Excellent computer proficiency (MS Word, Excel, Outlook).

 

 

Bioinformatics Scientist (Proteomics)

Bioinformatics Scientist (Proteomics)

Position Summary:

Gritstone Oncology is seeking a Bioinformatics Scientist (Proteomics) to help harness the immune system to treat cancer. The Bioinformatics Scientist will perform analyses of industry leading proprietary and public proteomic and genomic datasets to discover novel targets for cancer immunotherapy and develop other actionable biological insights. 

We are looking for an independent and flexible team player who will thrive in a fast-paced, dynamic, and highly collaborative environment. This is an opportunity to work for a well-funded early biotechnology company where bioinformatics analyses drive personalized cancer treatments.

 Specific responsibilities:

  • Design and implementation of computational methods for high-throughput analysis of mass spectrometry (e.g., HLA peptide sequencing) data. Refine methodologies for data storage, processing and visualization, and optimize performance and usability.
  • Analyze both small and large-scale biological data, integrating proteomics and genomics
  • In collaboration with the broader team, develop and improve methods to extract maximal biological insight from both internal and external data sources.
  • Effectively communicate findings to stakeholders

 Requirements:

Minimum Education/Experience:

  • PhD in Bioinformatics, Computer Science, Biostatistics, or a related field.  Or MS plus 3+ years of comparable work experience.
  • Significant experience working with proteomics data in a scientific research environment.
  • Expertise in numerical data analysis and scientific programming.
  • Self-motivated and able to work independently or in a small team with minimal supervision. Excellent communication and organizational skills.

 Qualifications:

Desired Experience:

  • In depth understanding of mass spectrometry laboratory techniques
  • Applying in-depth knowledge of cancer biology
  • Fluency in python including numpy/scipy/pandas
  • Software engineering including writing production-level code
  • Working in the cloud or on a high-performance computing cluster