Taking Immunotherapy to the Next Level

For cancer and infectious disease

Our Vision

Gritstone’s goal is to develop groundbreaking immunotherapies for cancers and infectious diseases. Our approach focuses on generating a therapeutic immune response in these patients by unleashing the natural power of a patient’s immune system to recognize and destroy tumors or virally-infected cells. It is well-established that one fundamental driver of an effective immune response is T cell recognition of abnormal cells and the proliferation of sufficient quantities of T cells to drive a potent attack against these cells, whether they are cancerous or virally-infected. Inspired by this, we: 1) built a best-in-class artificial intelligence driven platform to accurately identify T cell targets; and 2) developed a portfolio of immunotherapies designed to effectively instruct the immune system to recognize and attack these targets. We believe that activating and directing the immune system in this unique way can offer an important opportunity to extend the benefits of immunotherapy to more patients.

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What is a Tumor Antigen?

A small protein on the surface of a tumor cell that functions as the target for T cell mediated tumor death.

1.
Lineage
Specific

Antigens restricted to a certain normal cell type or lineage

2.
Shared Tumor-Associated Antigens

Antigens present in normal cells and overexpressed in cancer cells

3.
Shared Tumor-Specific Antigens

Antigens found in testis and tumor tissue that are functionally tumor specific

4.
Tumor-Specific Neoantigens

Antigens derived from mutated proteins in tumor cells

Increasing Tumor Specificity
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Engaging the Immune System Against Cancer

Leveraging our artificial intelligence Gritstone EDGE™ platform, as well as our expertise in cancer genomics, Gritstone is developing multiple immunotherapies designed to direct a robust immune response to neoantigens. We are developing two key classes of tumor-specific neoantigen product candidates to treat patients with cancer.

Personalized

Many tumor mutations are unique to each individual patient. For patients with neoantigens arising from patient-specific mutations, we believe that an immunotherapy made specifically for each patient has the potential to drive a potent immune response. GRANITE is Gritstone’s personalized immunotherapy.

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Off-the-Shelf

Some cancer mutations, known as driver mutations, recur between different cancer patients. Neoantigens that arise from these driver mutations and are shared between selected patients may be able to be used for an off-the-shelf neoantigen therapy. SLATE is Gritstone’s investigational off-the-shelf immunotherapy.

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Engaging the Immune System Against Infectious Disease

COVID-19 Prevention

First generation COVID-19 vaccines focused on eliciting a strong neutralizing antibody response against the surface Spike protein of SARS-CoV-2, the virus that causes COVID-19, and they have been shown to offer good initial protection; however, durability of protection is unknown and may be affected by mutations in the virus. Indeed mutations in the Spike protein are now appearing and spreading throughout the world, and some have the potential to reduce the neutralizing efficiency of the antibody response. T cells offer a key second layer of defense and may provide longer, more robust immunity. Using both Spike and other validated viral antigens that have been identified through studies of COVID-19 patients, as well as our platform technologies, Gritstone is developing a vaccine against COVID-19 that has the potential to maximize both T cell and antibody responses.

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Human Immunodeficiency Virus (HIV) Treatment

Gritstone and Gilead Sciences established a collaboration to research and develop a vaccine-based immunotherapy as part of Gilead’s efforts to find a curative treatment for human immunodeficiency virus (HIV) infection. The companies are developing an HIV-specific therapeutic vaccine using Gritstone’s proprietary prime-boost vaccine platform, comprised of self-amplifying mRNA (SAM) and adenoviral vectors.

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Pleasanton, CA

Gritstone’s Pleasanton facility houses our manufacturing capabilities and is fully equipped with multiple clean rooms, quality control and assurance, and development labs.

Emeryville, CA

Gritstone’s Emeryville facility is our corporate headquarters and includes our immunotherapy platform research lab and development team.

Cambridge, MA

Gritstone’s Cambridge facility includes our GMP sequencing lab, immune monitoring, and mass spec immunopeptidomics capabilities.

Our Facilities

With antigen-specific immunotherapy products, there are many areas of development that require exceptional expertise and execution. Each of Gritstone’s three facilities have specialized capabilities and personnel with the technical know-how that we believe is required to build the next generation of targeted immunotherapies.

Meet Our Leadership

Gritstone has assembled a group of distinguished scientific founders and advisers, a highly experienced leadership team, and a seasoned board of directors to tackle fundamental challenges at the intersection of cancer genomics and immunotherapy.

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Andrew Allen, M.D., Ph.D.
Co-founder, President and Chief Executive Officer
Matthew Hawryluk, Ph.D.
Executive Vice President and Chief Business Officer
Erin E. Jones, M.S.
Chief Operating Officer
Karin Jooss, Ph.D.
Head of Research & Development
Raphaël F. Rousseau, M.D., Ph.D.
Executive Vice President and Chief Medical Officer
Rahsaan W. Thompson, J.D.
Executive Vice President and General Counsel
Vijay Yabannavar, Ph.D.
Executive Vice President, Chief Manufacturing and Technical Operations Officer
Roman Yelensky, Ph.D.
Executive Vice President and Chief Technology Officer

Join Our Team

At Gritstone, we are committed to progressing the field of immunotherapy. One of our goals to eradicate cancer by initially developing personalized immunotherapies that focus on the unique and individual nature of a patient’s tumor. Another goal is to combat infectious diseases. Our first program is designed to halt the current pandemic and prevent COVID-19 with a next generation vaccine, and our second program is being developed in collaboration with Gilead Sciences for the treatment of HIV. Our dynamic team combines novel science with a focus on teamwork, and we are looking for passionate, innovative people to join us.

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